Summarizes the state of the art in the management of locally advanced and metastatic prostate cancer Evaluates the role of abiraterone and enzalutamide, docetaxel-based chemotherapy, and novel agents Discusses surgical approaches and the role of adjuvant and neoadjuvant therapy Examines current radiotherapy techniques This textbook summarizes the state of the art in the management of locally advanced and metastatic prostate cancer to provide the knowledge required for optimal treatment decision making in individual cases. Readers will find comprehensive coverage of the latest developments in surgery, radiotherapy, androgen deprivation therapy (ADT), chemotherapy, and immunotherapy. The role of the hormonal therapies abiraterone and enzalutamide and docetaxel-based chemotherapy in castration-resistant prostate cancer and hormone-sensitive metastatic disease is carefully evaluated. Among the other therapies discussed are LHRH agonists and antagonists, cabazitaxel, radium-223, and variou